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Dietary and serum vitamin D and preeclampsia risk in Chinese pregnant women: a matched case–control study

Mrs Amoah, Adwoa Nyantakyiwaa
Lecturer
  0202490030/0244983163
  adwoason@gmail.com
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Authors
 Huang, X. M., Liu, Y. H., Zhang, H., Cao, Y., Dou, W. F., Duan, D. D., Chen HN, Bo Y, Amoah A.N, Fu WJ, Zhao XL. & Lyu, Q. J.
Publication Year
2022
Article Title
Dietary and serum vitamin D and preeclampsia risk in Chinese pregnant women: a matched case–control study
Journal
British Journal of Nutrition
Volume
Volume 128
Issue Number
Issue 1
Page Numbers
pp. 84 - 92
Abstract

Abstract

The effect of vitamin D (VD) on the risk of preeclampsia (PE) is uncertain. Few previous studies focused on the relationship between dietary VD intake and PE risk. Therefore, we conducted this 1:1 matched case-control study to explore the association of dietary VD intake and serum VD concentrations with PE risk in Chinese pregnant women. A total of 440 pairs of participants were recruited from March 2016 to June 2019. Dietary information was obtained using a seventy-eight-item semi-quantitative FFQ. Serum concentrations of 25(OH)D2 and 25(OH)D3 were measured by liquid chromatography-tandem MS. Multivariate conditional logistic regression was used to estimate OR and 95 % CI. Restricted cubic splines (RCS) were plotted to evaluate the dose-response relationship of dietary VD intake and serum VD concentrations with PE risk. Compared with the lowest quartile, the OR of the highest quartile were 0·45 (95 % CI 0·29, 0·71, Ptrend = 0·001) for VD dietary intake and 0·26 (95 % CI 0·11, 0·60, Ptrend = 0·003) for serum levels after adjusting for confounders. In addition, the RCS analysis suggested a reverse J-shaped relationship between dietary VD intake and PE risk (P-nonlinearity = 0·02). A similar association was also found between serum concentrations of a total of 25(OH)D and PE risk (P-nonlinearity = 0·02). In conclusion, this study provides evidence that higher dietary intake and serum levels of VD are associated with a lower risk of PE in Chinese pregnant women.

Keywords

Preeclampsia Vitamin D ChinesePregnant women case-control study

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