Skip to main content

Calcium–Permeable Channels and Endothelial Dysfunction in Acute Lung Injury

Mr. Frimpong, Francis
Lecturer
+233 24 462 6224
ffrmpong@uew.edu.gh

Authors
Hao, Y., Wang, Z., Frimpong, F., & Chen, X.
Publication Year
2022
Article Title
Calcium–Permeable Channels and Endothelial Dysfunction in Acute Lung Injury
Journal
Current Issues in Molecular Biology
Volume
44
Issue Number
5
Page Numbers
2217-2229
Abstract

The increased permeability of the lung microvascular endothelium is one critical initiation of acute lung injury (ALI). The disruption of vascular-endothelium integrity results in leakiness of the endothelial barrier and accumulation of protein-rich fluid in the alveoli. During ALI, increased endothelial-cell (EC) permeability is always companied by high frequency and amplitude of cytosolic Ca2+ oscillations. Mechanistically, cytosolic calcium oscillations include calcium release from internal stores and calcium entry via channels located in the cell membrane. Recently, numerous publications have shown substantial evidence that calcium-permeable channels play an important role in maintaining the integrity of the endothelium barrier function of the vessel wall in ALI. These novel endothelial signaling pathways are future targets for the treatment of lung injury. This short review focuses on the up-to-date research and provide insight into the contribution of calcium influx via ion channels to the disruption of lung microvascular endothelial-barrier function during ALI.

© 2019 University of Education, Winneba